prothionamide [Drug Class]

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Accession ARO:3004025
DefinitionProthionamide is a thioamide derivative with antibacterial properties. It increases cell wall permeability and decreases cell wall damage resistance by inhibition of mycolic acid synthesis, resulting in cell death. It is particularly used to treat M. tuberculosis and M. leprae infections.
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Matsuo Y, et al. 1981. Int. J. Lepr. Other Mycobact. Dis. 49(3):302-6 Prothionamide and prothionamide-S-oxide in experimental leprosy. (PMID 6459296)