aminosalicylate resistant thymidylate synthase [AMR Gene Family]

Accession ARO:3004152
DefinitionAntibiotic resistant form of thymidylate synthase (synthetase), an enzyme that catalyzes the conversion of dUMP to dTMP in nucleotide biosynthesis. Loss-of-function mutations in thymidylate synthase confer resistance to p-aminosalicylic acid by disrupting the substrate-binding affinity and catalytic activity.
Drug Classsalicylic acid antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show