antibiotic sensitive thymidylate synthase

Accession ARO:3004154
Synonym(s)antibiotic sensitive thyA
DefinitionThymidylate synthase (synthetase) catalyzes the conversion of dUMP to dTMP in the nucleic acid biosynthesis pathway. Inhibition of thyA imbalances the cellular concentration of dUMP causing DNA damage.
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show
+ aminosalicylate resistant thymidylate synthase [AMR Gene Family] derives_from

Zhang X, et al. 2015. Antimicrob. Agents Chemother. 59(2):1320-4 Genetic determinants involved in p-aminosalicylic acid resistance in clinical isolates from tuberculosis patients in northern China from 2006 to 2012. (PMID 25421465)