aminosalicylate resistant dihydrofolate synthase [AMR Gene Family]

Accession ARO:3004155
DefinitionDihydrofolate synthase (synthetase) enzymes resistant to aminosalicylates (inc. para-aminosalicylic acid) caused by mutation. Dihydrofolate synthase is required for bioactivation of p-aminosalicylic acid, and mutation in dihydrofolate synthase inhibits production of the dihydrofolate analog hydroxyl-dihydrofolate, thus preventing activation and conferring resistance.
Drug Classsalicylic acid antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
1 ontology terms | Show