antibiotic resistant fabI [AMR Gene Family]

Accession ARO:3004270
DefinitionfabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid.
Drug Classdisinfecting agents and antiseptics, isoniazid-like antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ derives_from antibiotic sensitive fabI
+ confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class]
+ confers_resistance_to_drug_class isoniazid-like antibiotic [Drug Class]
1 ontology terms | Show

Khan R, et al. 2016. Sci Rep 6:32322 Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes. (PMID 27577999)