antibiotic resistant fabI [AMR Gene Family]

Accession ARO:3004270
DefinitionfabI is a enoyl-acyl carrier reductase used in lipid metabolism and fatty acid biosynthesis. The bacterial biocide Triclosan blocks the final reduction step in fatty acid elongation, inhibiting biosynthesis. Point mutations in fabI can confer resistance to Triclosan and Isoniazid.
Drug Classisoniazid, triclosan
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class isoniazid [Drug Class]
+ confers_resistance_to_drug_class triclosan [Drug Class]
+ derives_from antibiotic sensitive fabI
1 ontology terms | Show

Khan R, et al. 2016. Sci Rep 6:32322 Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes. (PMID 27577999)