bulgecin A [Adjuvant]

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Accession ARO:3004296
DefinitionBulgecin A is a lytic transglycosylase inhibitor and antibiotic potentiator produced from Pseudomonas mesoacidophila. In the presence of some beta-lactam antibiotics, including ampicillin and meropenem, bulgecin A has been shown to restore susceptibility to carbapenems in carbapenem-resistant pathogens.
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Skalweit MJ, et al. 2016. Drug Des Devel Ther 10:3013-3020 Bulgecin A as a β-lactam enhancer for carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii clinical isolates containing various resistance mechanisms. (PMID 27703329)