Bi-component hemolysin

Accession VIRO:0000233
DefinitionHemolysin toxin which assembles their pore-forming unit using two unique polypeptides, generally an S-class (slow) unit and F-class (fast) unit. The structure is generally accepted to be comprised of an octameric core of alternating S and F units, with S being generally responsible for binding to cells and subsequently recruiting the F unit(s).
Classification8 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ Hemolysin toxins [Virulence Factor]
1 ontology terms | Show

Vandenesch F, et al. 2012. Front Cell Infect Microbiol 2:12 Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?. (PMID 22919604)

DuMont AL, et al. 2014. Trends Microbiol. 22(1):21-7 Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids. (PMID 24231517)