| Accession | VIRO:0000251 |
| Synonym(s) | CUP |
| Definition | Chaperone-Usher pili use the chaperone-usher pathway to assemble their pili. These pili can be classified phylogenetically based on their usher protein sequence. There are six phylogenetic clades, including alpha-, beta-, gamma-, kappa, pi-, and sigma-fimbriae. The alpha-clade contains pili from the alternate chaperone-usher pili (Class 5 fimbriae). The beta-clade fimbriae are previously classified members of the fimbrial usher protein (FUP) cluster 7. The gamma-clade is subdivided into four clades: 1) type I fimbriae-like pili; 2) FUP cluster 2 adhesins; 3) FGL (long F1-G1 loop afimbrial) adhesins; and, 4) FUP family 10. The kappa-clade encodes flexible fimbriae, and contains proteins that assemble the F4, F5, and F8 fimbrial antigen. The pi-clade include the P pilus and other similar pili. The sigma-clade contains archaic chaperone-usher systems. |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + adhesin [Virulence Factor] |
| Sub-Term(s) | 6 ontology terms | Show |
| Publications | Nuccio SP and Baumler AJ. 2007. Microbiol Mol Biol Rev 71(4): 551-575. Evolution of the chaperone/usher assembly pathway: fimbrial classification goes Greek. (PMID 18063717) |