Ontology | Virulence Ontology |
Accession | VIRO:0000375 |
Definition | Group of toxins which exert their toxic effect by mimicking the natural regulators of Rho proteins in order to modify actin polymerization within the host cell. Activation is generally achieved by mimicking the function of GEFs (guanine nucleotide exchange factors). Inactivation is generally achieved by mimicking the function of GAPs (GTPase-activating proteins). |
Classification | 6 ontology terms | Show + process or component of pathogenesis biology or chemistry + biological effect of virulence + virulence factor + host cell damaging + toxin [Virulence Factor] + exotoxin |
Parent Term(s) | 1 ontology terms | Show + Actin-affecting toxins [Virulence Mechanism] |
Sub-Term(s) | 2 ontology terms | Show |
Publications | Aktories K, et al. 2017. Handb Exp Pharmacol 235:179-206 ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (PMID 27316913) |
Curator | Description | Most Recent Edit |
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