GAP-mimicking toxins

Accession VIRO:0000376
Synonym(s)GAP toxins GTPase-activating proteins-mimicking toxins
DefinitionGroup of toxins which exert their toxic effect by mimicking the naturally occurring GTPase-activating proteins (GAPs) which function by switching off the active state of Rho proteins resulting in inhibition of G actin polymerization and/or F actin depolymerization
Classification7 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show

Aktories K, et al. 2017. Handb Exp Pharmacol 235:179-206 ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (PMID 27316913)