Accession VIRO:0000465
Synonym(s)Thermostable direct hemolysin
DefinitionThermostable direct hemolysin (TDH) is found in Vibrio parahaemolyticus. The hemolytic activity of TDH has been well characterized and discussed. TDH forms pores of approximately 2 nm on erythrocyte membranes and causes colloidal osmotic lysis and is therefore considered to function as a pore-forming toxin. The pore formed as a result of this toxin allows for both ions and water to pass through. The altered ion flow is what is responsible for diarrhea in patients affected by this toxin.
Classification11 ontology terms | Show
Parent Term(s)4 ontology terms | Show

Matsuda S, et al. 2010. Infect. Immun. 78(2):603-10 Association of Vibrio parahaemolyticus thermostable direct hemolysin with lipid rafts is essential for cytotoxicity but not hemolytic activity. (PMID 19933828)

Raghunath P, et al. 2014. Front Microbiol 5:805 Roles of thermostable direct hemolysin (TDH) and TDH-related hemolysin (TRH) in Vibrio parahaemolyticus. (PMID 25657643)

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