telA

Accession VIRO:0000783
DefinitionToxin exported by Esx with LXG domain A: an LXG toxin isolated from Streptococcus intermedius B196 that inhibits bacterial growth
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Publications

Whitney JC, et al. 2017. Elife 6: A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria. (PMID 28696203)

Resistomes

Prevalence of telA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 575


>gb|AGU75561.1|+|telA [Streptococcus intermedius B196]
MKIDMTEVNNQKTALANSISNLNGQIDTAKNSLTNLTSSSSLTGDVKTAIDAKINNYQVPLLTNFTNALTTLSAQYDKTIEQFQSTVSEN
AADAVIDTDYLQGLLDNYSGIETSISTINTETSTIYSSISDIISLTNPDSSTITTPLAAAKTILTDTKTNMESFNGWTRGTELADLLLSQ
TQTIETLIGYASSGYTAADAKSFYNNNEFLQGVNKIAEAIANSTPVELLANISNTLNGFVRSNISWWKKFITDSKGKRAMASGKIWVDDE
GQLHADGSAEAAAFLADLDTSGEFEIAGVKFNGEGKAFVGAKAAANIKANLTKDGIDVTAHAEAMLGVSASASGGFTVGSGILAAKGDAK
VEAMAGAWANADGSVTFDKTGLEAKASASAKAGAEASGSADLTLGDTSHGITQAQVGVSGDAFAGAKASADASFGVKNNGEVAASANASA
FAGAQAKGEAHGKALYTTFSVEGSAKAGIGGEVGASFKKEGGHLDIDLNLGASLGLGLGGRVKADFDYGSALKDIQDFGKWLTGSK


>gb|CP003857.1|+|165844-167454|telA [Streptococcus intermedius B196]
ATGAAGATAGATATGACGGAGGTTAATAATCAAAAGACTGCTTTAGCAAATTCTATTTCAAATTTGAATGGTCAAATAGATACTGCAAAA
AATTCATTAACAAATCTAACTAGTTCAAGTAGCTTGACCGGAGATGTTAAAACAGCTATTGATGCTAAGATTAATAATTATCAAGTTCCT
TTATTGACTAACTTTACAAATGCTTTGACAACCTTATCGGCACAATATGATAAAACAATCGAACAGTTTCAAAGTACAGTATCTGAGAAT
GCTGCAGATGCGGTTATTGATACAGATTATTTACAAGGGCTTTTAGATAATTATTCAGGAATTGAAACAAGCATCTCTACTATTAATACG
GAAACTTCTACAATCTATTCATCCATTTCGGATATTATCTCTTTGACAAATCCAGATAGTTCAACGATTACAACTCCTCTGGCAGCTGCC
AAAACGATTCTAACTGATACAAAAACAAATATGGAAAGTTTTAACGGCTGGACAAGGGGAACTGAGCTTGCAGATTTACTGCTTTCTCAA
ACACAAACTATTGAAACTTTAATAGGTTATGCGTCCAGCGGTTATACTGCAGCAGACGCTAAAAGCTTTTACAATAATAACGAGTTTTTG
CAAGGGGTTAACAAAATTGCTGAAGCTATCGCAAATTCGACTCCTGTAGAACTTTTAGCAAATATATCAAATACGCTAAATGGTTTTGTT
CGTTCAAATATATCTTGGTGGAAAAAATTCATTACTGATTCAAAAGGAAAACGTGCAATGGCATCAGGGAAAATATGGGTTGATGACGAA
GGACAACTTCATGCTGATGGTAGTGCAGAAGCGGCAGCATTTTTGGCTGATTTGGATACTAGTGGCGAATTTGAAATTGCAGGCGTTAAA
TTCAATGGTGAAGGCAAAGCTTTTGTGGGCGCTAAAGCAGCCGCCAATATAAAAGCCAATTTGACAAAAGATGGAATTGATGTAACAGCG
CATGCTGAGGCTATGCTTGGTGTATCTGCATCTGCAAGTGGTGGTTTTACTGTAGGTTCAGGTATTTTAGCTGCTAAAGGTGATGCCAAA
GTAGAAGCGATGGCTGGTGCTTGGGCGAATGCTGATGGTAGTGTAACTTTTGATAAAACAGGGTTAGAAGCTAAGGCTTCTGCTTCTGCA
AAAGCTGGAGCAGAAGCAAGCGGAAGTGCAGATCTTACTCTAGGAGATACTAGTCATGGAATTACTCAGGCCCAGGTGGGGGTTTCTGGA
GATGCTTTTGCTGGTGCTAAGGCCAGTGCTGATGCTTCTTTCGGAGTTAAAAATAATGGAGAGGTGGCAGCTTCAGCTAATGCCAGTGCT
TTTGCTGGTGCACAAGCGAAAGGGGAGGCGCATGGCAAGGCGCTTTATACAACATTTAGTGTAGAAGGATCAGCTAAGGCTGGTATAGGT
GGAGAAGTTGGTGCTAGCTTTAAAAAAGAAGGTGGTCATCTAGATATTGATTTAAATCTAGGAGCCTCTTTAGGTTTAGGCCTTGGAGGC
CGTGTTAAGGCTGACTTTGATTATGGTTCAGCGCTTAAAGATATACAAGACTTCGGTAAGTGGCTTACTGGTTCTAAATAG