prothionamide resistant katG [AMR Gene Family]

Accession ARO:3005101
DefinitionMutations associated with katG conferring resistance to prothionamide, an analogue of isoniazid. Like isoniazid, prothionamide targets lnhA.
Drug Classthioamide antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant katG
+ confers_resistance_to_drug_class thioamide antibiotic [Drug Class]
1 ontology terms | Show

Islam MM, et al. 2019. Clin. Microbiol. Infect. 25(8):1041.e1-1041.e7 Detection of novel mutations associated with independent resistance and cross-resistance to isoniazid and prothionamide in Mycobacterium tuberculosis clinical isolates. (PMID 30583053)