| Accession | ARO:3005162 |
| CARD Short Name | FosA7.5 |
| Definition | FosA7.5 is a variant of the FosA7 gene. This gene is unique from FosA7 in that it is found in Escherichia coli as opposed to Salmonella enterica. It confers resistance to fosfomycin. |
| AMR Gene Family | fosfomycin thiol transferase |
| Drug Class | phosphonic acid antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Citrobacter koserig+wgs, Enterobacter hormaecheiwgs, Escherichia colig+p+wgs, Shigella flexneriwgs, Shigella sonneiwgs |
| Resistomes with Sequence Variants | Citrobacter koserig+wgs, Enterobacter hormaecheiwgs, Escherichia colig+p+wgs, Klebsiella aerogeneswgs, Salmonella entericawgs, Shigella flexneriwgs, Shigella sonneiwgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + phosphonic acid antibiotic [Drug Class] + fosfomycin inactivation enzyme + hydrolysis of fosfomycin epoxide ring |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic fosfomycin [Antibiotic] + fosfomycin thiol transferase [AMR Gene Family] |
| Publications | Milner KA, et al. 2020. Antimicrob Agents Chemother : Identification and characterization of a novel FosA7 member from fosfomycin resistant Escherichia coli clinical isolates from Canadian hospitals. (PMID 33077665) |
Prevalence of FosA7.5 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter koseri | 6.25% | 0% | 5.41% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.09% | 0% |
| Escherichia coli | 0.57% | 0.01% | 0.79% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.28% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Shigella flexneri | 0% | 0% | 0.31% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 280