thiosemicarbazone antibiotic [Drug Class]

Accession ARO:3007161
DefinitionA group of antibiotics derived from thiosemicarbazide (possessing the thiosemicarbazone functional group).
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show
+ thioacetazone [Antibiotic]
+ perchlozone [Antibiotic]
+ perchlozone resistant ethA [AMR Gene Family] confers_resistance_to_drug_class

Alahari A, et al. 2007. PLoS ONE 2(12):e1343 Thiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteria. (PMID 18094751)

Mokrousov I, et al. 2020. Antibiotics (Basel) 9(10): Genetic Variation Putatively Associated with Mycobacterium tuberculosis Resistance to Perchlozone, a New Thiosemicarbazone: Clues from Whole Genome Sequencing and Implications for Treatment of Multidrug-Resistant Tuberculosis. (PMID 33022959)