D-LANA14 [Adjuvant]

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Accession ARO:3007317
DefinitionD-LANA-14 is a d-lysine conjugated aliphatic norspermidine analogue that has been shown to increase the permeability of Gram-negative membranes and enhance the entry of antibiotics. It is also able to inhibit the formation of bacterial biofilms.
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Konai MM, et al. 2020. ACS Infect Dis 6(1):91-99 Lysine-Based Small Molecule Sensitizes Rifampicin and Tetracycline against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. (PMID 31646866)

Konai MM, et al. 2017. Bioconjug Chem 28(4):1194-1204 Fatty Acid Comprising Lysine Conjugates: Anti-MRSA Agents That Display In Vivo Efficacy by Disrupting Biofilms with No Resistance Development. (PMID 28225264)