Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3007320 |
Definition | Phenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing. |
SMILES | N=C(N)NCCC[C@H](NC(=O)[C@@H](N)Cc1ccccc1)C(=O)Nc1ccc2ccccc2c1 |
PubChem | 443301 |
ChEMBL | CHEMBL56252 |
Classification | 3 ontology terms | Show |
Parent Term(s) | 3 ontology terms | Show |
Publications | Lamers RP, et al. 2013. PLoS One 8(3):e60666 The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. (PMID 23544160) Elsheredy A, et al. 2021. Iran J Microbiol 13(1):37-49 Effect of azithromycin and phenylalanine-arginine beta-naphthylamide on quorum sensing and virulence factors in clinical isolates of Pseudomonas aeruginosa. (PMID 33889361) |
Curator | Description | Most Recent Edit |
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