phenylalanine-arginine beta-naphthylamide [Adjuvant]

Download Sequences

Accession ARO:3007320
DefinitionPhenylalanine-arginine beta-naphthylamide is a widely-used experimental efflux pump inhibitor. It has also been shown to increase Gram-negative membrane permeability and enhance the entry of antibiotics, even in efflux pump deficient strains. It is also able to inhibit the formation of bacterial biofilms and disrupt quorum sensing.
Classification3 ontology terms | Show
Parent Term(s)3 ontology terms | Show

Lamers RP, et al. 2013. PLoS One 8(3):e60666 The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. (PMID 23544160)

Elsheredy A, et al. 2021. Iran J Microbiol 13(1):37-49 Effect of azithromycin and phenylalanine-arginine beta-naphthylamide on quorum sensing and virulence factors in clinical isolates of Pseudomonas aeruginosa. (PMID 33889361)