| Accession | ARO:3007368 |
| CARD Short Name | FosG |
| Definition | FosG is a glutathione transferase that confers resistance to fosfomycin. |
| AMR Gene Family | fosfomycin thiol transferase |
| Drug Class | phosphonic acid antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Aeromonas caviaeg+p+wgs, Aeromonas enteropelogeneswgs, Enterobacter hormaecheip, Klebsiella pneumoniaewgs, Vibrio alginolyticuswgs, Vibrio choleraeg+wgs, Vibrio metoecusg+wgs, Vibrio owensiiwgs, Vibrio parahaemolyticusg+wgs, Vibrio vulnificusg+wgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of fosfomycin epoxide ring + phosphonic acid antibiotic [Drug Class] + fosfomycin inactivation enzyme |
| Parent Term(s) | 2 ontology terms | Show + fosfomycin thiol transferase [AMR Gene Family] + confers_resistance_to_antibiotic fosfomycin [Antibiotic] |
| Publications | Khabthani S, et al. 2021. Antimicrob Agents Chemother 65(2): fosM, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota. (PMID 33199384) |
Prevalence of FosG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Aeromonas caviae | 88.64% | 1.3% | 65.05% | 0% |
| Aeromonas enteropelogenes | 0% | 0% | 12.5% | 0% |
| Enterobacter hormaechei | 0% | 0.06% | 0% | 0% |
| Escherichia coli | 0% | 0% | 0% | 0% |
| Klebsiella pneumoniae | 0% | 0% | 0.01% | 0% |
| Vibrio alginolyticus | 0% | 0% | 4.37% | 0% |
| Vibrio cholerae | 0.45% | 0% | 0.06% | 0% |
| Vibrio metoecus | 12.5% | 0% | 4% | 0% |
| Vibrio owensii | 0% | 0% | 15.79% | 0% |
| Vibrio parahaemolyticus | 0.65% | 0% | 1.7% | 0% |
| Vibrio vulnificus | 1.82% | 0% | 1.63% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 175