| Accession | ARO:3007370 |
| CARD Short Name | FosI |
| Definition | FosI is a fosfomycin resistance gene. |
| AMR Gene Family | fosfomycin thiol transferase |
| Drug Class | phosphonic acid antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Enterobacter roggenkampiip, Providencia rettgerip, Pseudomonas monteiliip |
| Resistomes with Sequence Variants | Citrobacter freundiiwgs, Clostridium botulinumg+wgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip, Enterococcus faecaliswgs, Enterococcus faeciumg+wgs, Klebsiella pneumoniaep+wgs, Listeria monocytogeneswgs, Pannonibacter phragmitetusg+wgs, Providencia rettgerip, Pseudomonas aeruginosap, Pseudomonas monteiliip, Rhodanobacter glyciniswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + phosphonic acid antibiotic [Drug Class] + fosfomycin inactivation enzyme + hydrolysis of fosfomycin epoxide ring |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic fosfomycin [Antibiotic] + fosfomycin thiol transferase [AMR Gene Family] |
| Publications | Pelegrino Kde O, et al. 2016. Antimicrob Agents Chemother 60(1):686-8 fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin. (PMID 26552984) |
Prevalence of FosI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter freundii | 0% | 0% | 0.19% | 0% |
| Clostridium botulinum | 2.99% | 0% | 0.54% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.04% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Enterobacter roggenkampii | 0% | 0.48% | 0% | 0% |
| Enterococcus faecalis | 0% | 0% | 0.08% | 0% |
| Enterococcus faecium | 1.27% | 0% | 9.26% | 0% |
| Klebsiella pneumoniae | 0% | 0.01% | 0.01% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.02% | 0% |
| Pannonibacter phragmitetus | 100% | 0% | 83.33% | 0% |
| Providencia rettgeri | 0% | 2.7% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 0.58% | 0% | 0% |
| Pseudomonas monteilii | 0% | 14.29% | 0% | 0% |
| Rhodanobacter glycinis | 0% | 0% | 33.33% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 100