Accession ARO:3007370
CARD Short NameFosI
DefinitionFosI is a fosfomycin resistance gene.
AMR Gene Familyfosfomycin thiol transferase
Drug Classphosphonic acid antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesEnterobacter roggenkampiip, Providencia rettgerip, Pseudomonas monteiliip
Resistomes with Sequence VariantsCitrobacter freundiiwgs, Clostridium botulinumg+wgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Enterobacter roggenkampiip, Enterococcus faecaliswgs, Enterococcus faeciumg+wgs, Klebsiella pneumoniaep+wgs, Listeria monocytogeneswgs, Pannonibacter phragmitetusg+wgs, Providencia rettgerip, Pseudomonas aeruginosap, Pseudomonas monteiliip, Rhodanobacter glyciniswgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ fosfomycin thiol transferase [AMR Gene Family]
+ confers_resistance_to_antibiotic fosfomycin [Antibiotic]

Pelegrino Kde O, et al. 2016. Antimicrob Agents Chemother 60(1):686-8 fosI Is a New Integron-Associated Gene Cassette Encoding Reduced Susceptibility to Fosfomycin. (PMID 26552984)


Prevalence of FosI among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Citrobacter freundii0%0%0.19%0%
Clostridium botulinum2.99%0%0.54%0%
Enterobacter hormaechei0%0%0.04%0%
Enterobacter kobei0%0%0.44%0%
Enterobacter roggenkampii0%0.48%0%0%
Enterococcus faecalis0%0%0.08%0%
Enterococcus faecium1.27%0%9.26%0%
Klebsiella pneumoniae0%0.01%0.01%0%
Listeria monocytogenes0%0%0.02%0%
Pannonibacter phragmitetus100%0%83.33%0%
Providencia rettgeri0%2.7%0%0%
Pseudomonas aeruginosa0%0.58%0%0%
Pseudomonas monteilii0%14.29%0%0%
Rhodanobacter glycinis0%0%33.33%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 100

>gb|AFJ38137.1|-|FosI [Mycobacteroides abscessus subsp. bolletii F1725]

>gb|CP003505.2|-|17008-17412|FosI [Mycobacteroides abscessus subsp. bolletii F1725]