| Accession | ARO:3007371 |
| CARD Short Name | FosA8 |
| Definition | FosA8 is a plasmid-located fosfomycin resistance gene. |
| AMR Gene Family | fosfomycin thiol transferase |
| Drug Class | phosphonic acid antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Enterobacter hormaecheiwgs, Escherichia colip+wgs, Klebsiella pneumoniaep, Leclercia adecarboxylatawgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Acinetobacter calcoaceticuswgs, Acinetobacter johnsoniiwgs, Acinetobacter juniiwgs, Acinetobacter nosocomialisg+wgs, Acinetobacter pittiig+wgs, Aeromonas caviaeg+wgs, Aeromonas enteropelogenesg+wgs, Aeromonas veroniig+wgs, Alcaligenes faecalisg+wgs, Bordetella trematumg+wgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiiwgs, Citrobacter koseriwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Comamonas testosteronig+wgs, Cronobacter condimentig+wgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Enterobacter cloacaewgs, Enterobacter hormaecheiwgs, Enterobacter kobeiwgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Inquilinus limosuswgs, Klebsiella aerogeneswgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaewgs, Leclercia adecarboxylatag+wgs, Legionella pneumophilag+wgs, Morganella morganiig+wgs, Orientia tsutsugamushiwgs, Proteus columbaewgs, Proteus mirabilisg+wgs, Proteus vulgarisg+wgs, Providencia alcalifacienswgs, Providencia rettgerig+wgs, Providencia stuartiig+wgs, Pseudomonas aeruginosawgs, Pseudomonas brassicacearumg+wgs, Pseudomonas chlororaphisg+wgs, Pseudomonas fluorescensg+wgs, Pseudomonas koreensiswgs, Pseudomonas putidag+wgs, Pseudomonas synxanthag+wgs, Pseudomonas syringaewgs, Ralstonia pickettiiwgs, Rhodanobacter glycinisg+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferag+wgs, Serratia rubidaeag+wgs, Vibrio owensiig+wgs, Vibrio parahaemolyticuswgs |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + phosphonic acid antibiotic [Drug Class] + fosfomycin inactivation enzyme + hydrolysis of fosfomycin epoxide ring |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic fosfomycin [Antibiotic] + fosfomycin thiol transferase [AMR Gene Family] |
| Publications | Poirel L, et al. 2019. Antimicrob Agents Chemother 63(11): Identification of FosA8, a Plasmid-Encoded Fosfomycin Resistance Determinant from Escherichia coli, and Its Origin in Leclercia adecarboxylata. (PMID 31481445) |
Prevalence of FosA8 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 2.12% | 0% | 1.24% | 0% |
| Acinetobacter calcoaceticus | 0% | 0% | 4.35% | 0% |
| Acinetobacter johnsonii | 0% | 0% | 1.82% | 0% |
| Acinetobacter junii | 0% | 0% | 1.49% | 0% |
| Acinetobacter nosocomialis | 9.09% | 0% | 3.45% | 0% |
| Acinetobacter pittii | 13.51% | 0% | 7.39% | 0% |
| Aeromonas caviae | 4.55% | 0% | 1.61% | 0% |
| Aeromonas enteropelogenes | 100% | 0% | 62.5% | 0% |
| Aeromonas veronii | 5.45% | 0% | 5.62% | 0% |
| Alcaligenes faecalis | 5% | 0% | 2.94% | 0% |
| Bordetella trematum | 100% | 0% | 100% | 0% |
| Citrobacter amalonaticus | 18.18% | 0% | 9.09% | 0% |
| Citrobacter freundii | 0% | 0% | 0.58% | 0% |
| Citrobacter koseri | 0% | 0% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 0% | 1.8% | 0% |
| Citrobacter werkmanii | 0% | 0% | 5.13% | 0% |
| Comamonas testosteroni | 100% | 0% | 92.86% | 0% |
| Cronobacter condimenti | 100% | 0% | 100% | 0% |
| Cronobacter dublinensis | 100% | 0% | 92.31% | 0% |
| Cronobacter malonaticus | 100% | 0% | 76.36% | 0% |
| Cronobacter sakazakii | 100% | 0% | 90.13% | 0% |
| Enterobacter cloacae | 0% | 0% | 2.24% | 0% |
| Enterobacter hormaechei | 0% | 0% | 0.26% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Escherichia albertii | 4.29% | 0% | 1.94% | 0% |
| Escherichia coli | 0.02% | 0.04% | 0.04% | 0% |
| Inquilinus limosus | 0% | 0% | 25% | 0% |
| Klebsiella aerogenes | 0% | 0% | 1.13% | 0% |
| Klebsiella oxytoca | 0% | 0% | 0.42% | 0% |
| Klebsiella pneumoniae | 0.3% | 0.02% | 0.12% | 0% |
| Klebsiella quasipneumoniae | 0% | 0% | 0.13% | 0% |
| Leclercia adecarboxylata | 100% | 0% | 60.47% | 0% |
| Legionella pneumophila | 23.01% | 0% | 47.44% | 0% |
| Morganella morganii | 100% | 0% | 56.44% | 0% |
| Orientia tsutsugamushi | 0% | 0% | 25% | 0% |
| Proteus columbae | 0% | 0% | 50% | 0% |
| Proteus mirabilis | 11.93% | 0% | 8.09% | 0% |
| Proteus vulgaris | 27.27% | 0% | 16.67% | 0% |
| Providencia alcalifaciens | 0% | 0% | 3.45% | 0% |
| Providencia rettgeri | 97.06% | 0% | 54.14% | 0% |
| Providencia stuartii | 37.5% | 0% | 25% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.16% | 0% |
| Pseudomonas brassicacearum | 100% | 0% | 72% | 0% |
| Pseudomonas chlororaphis | 98.77% | 0% | 56.45% | 0% |
| Pseudomonas fluorescens | 50% | 0% | 36.96% | 0% |
| Pseudomonas koreensis | 0% | 0% | 13.04% | 0% |
| Pseudomonas putida | 1.41% | 0% | 2.67% | 0% |
| Pseudomonas synxantha | 100% | 0% | 87.5% | 0% |
| Pseudomonas syringae | 0% | 0% | 1.02% | 0% |
| Ralstonia pickettii | 0% | 0% | 1.27% | 0% |
| Rhodanobacter glycinis | 100% | 0% | 33.33% | 0% |
| Salmonella enterica | 1.26% | 0% | 1.21% | 0% |
| Serratia liquefaciens | 100% | 0% | 50.79% | 0% |
| Serratia marcescens | 98.48% | 1.29% | 77.59% | 0% |
| Serratia odorifera | 100% | 0% | 100% | 0% |
| Serratia rubidaea | 87.5% | 0% | 81.82% | 0% |
| Vibrio owensii | 50% | 0% | 68.42% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.36% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 100