FosBx1

Accession ARO:3007372
CARD Short NameFosBx1
DefinitionFosBx1 is a fosfomycin resistance gene.
AMR Gene Familyfosfomycin thiol transferase
Drug Classphosphonic acid antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Sequence VariantsBacillus amyloliquefaciensg+wgs, Bacillus anthracisg+wgs, Bacillus cereusg+wgs, Bacillus halotoleransg+wgs, Bacillus pumilusg+wgs, Bacillus subtilisg+wgs, Bacillus tequilensisg+wgs, Bacillus thuringiensisg+p+wgs, Bacillus velezensisg+wgs, Brevibacillus brevisg+wgs, Enterobacter roggenkampiiwgs, Macrococcus canisg, Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+p+wgs, Staphylococcus equorumg+wgs, Staphylococcus haemolyticuswgs, Staphylococcus intermediuswgs, Staphylococcus lugdunensisg+wgs, Staphylococcus massiliensiswgs, Staphylococcus pasteurig+wgs, Staphylococcus pseudintermediusg+wgs, Staphylococcus saprophyticusg+wgs, Staphylococcus warneriwgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ fosfomycin thiol transferase [AMR Gene Family]
+ confers_resistance_to_antibiotic fosfomycin [Antibiotic]
Publications

Khabthani S, et al. 2021. Antimicrob Agents Chemother 65(2): fosM, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota. (PMID 33199384)

Resistomes

Prevalence of FosBx1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus amyloliquefaciens97.14%0%77.53%0%
Bacillus anthracis10.66%0%6.58%0%
Bacillus cereus6.45%0%8.77%0%
Bacillus halotolerans90.91%0%81.08%0%
Bacillus pumilus50%0%15.08%0%
Bacillus subtilis95.34%0%73.99%0%
Bacillus tequilensis100%0%100%0%
Bacillus thuringiensis3.75%0.72%29.84%0%
Bacillus velezensis93.98%0%77.29%0%
Brevibacillus brevis100%0%90%0%
Enterobacter roggenkampii0%0%0.36%0%
Escherichia coli0%0%0%0%
Macrococcus canis7.14%0%0%0%
Staphylococcus arlettae33.33%0%75%0%
Staphylococcus aureus0.26%0%0.13%0%
Staphylococcus capitis70%0%30.38%0%
Staphylococcus epidermidis56.77%0.29%44.27%0%
Staphylococcus equorum25%0%25%0%
Staphylococcus haemolyticus0%0%0.88%0%
Staphylococcus intermedius0%0%12.5%0%
Staphylococcus lugdunensis97.22%0%24.62%0%
Staphylococcus massiliensis0%0%57.14%0%
Staphylococcus pasteuri50%0%26.92%0%
Staphylococcus pseudintermedius96.67%0%69.49%0%
Staphylococcus saprophyticus58.82%0%59.44%0%
Staphylococcus warneri0%0%9.02%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 150


>gb|QLF01382.1|+|FosBx1 [Bacillus cereus]
MLRGINHICFSVSNLENSIMFYEKVLEGELLVKGRKLAYFNICGVWIALNEETHIPRNEIHQSYTHIAFSVEKEDFKCLIQRLEENDVHI
LQGRERDVRDCESIYFVDPDGHKFEFHSGTLQDRLNYYRDEKPHMTFY


>gb|CP043966.1|+|1915972-1916388|FosBx1 [Bacillus cereus]
TTGTTAAGGGGAATCAATCATATTTGTTTTTCGGTATCTAATTTAGAAAACTCTATTATGTTTTATGAAAAAGTATTAGAAGGAGAATTA
TTAGTTAAAGGAAGAAAATTGGCTTATTTTAACATATGTGGAGTATGGATAGCGCTTAATGAAGAGACGCATATTCCGAGAAATGAGATT
CATCAATCTTATACGCACATTGCATTTTCTGTTGAAAAAGAAGACTTTAAATGTCTAATACAGCGATTAGAAGAAAATGATGTTCATATT
TTACAAGGAAGAGAACGTGATGTAAGAGATTGCGAATCTATATACTTTGTTGATCCTGACGGTCATAAATTTGAGTTTCACTCAGGGACA
CTGCAAGACCGTTTAAATTATTATAGAGATGAGAAACCTCATATGACATTTTATTAG