antibiotic resistant ATP synthase [AMR Gene Family]

Accession ARO:3007477
DefinitionATP synthase enzymes, specifically subunit C, resistant to diarylquinolone antibiotics including Bedaquiline. Mutations in ATP synthase confer antibiotic resistance by disrupting binding and blocking of ATP synthase reactions by Bedaquiline.
Drug Classdiarylquinoline antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ antibiotic resistant gene variant or mutant
+ confers_resistance_to_drug_class diarylquinoline antibiotic [Drug Class]
1 ontology terms | Show

Calvet-Seral J, et al. 2023. Microbiol Spectr :e0534422 Targeted Chromosomal Barcoding Establishes Direct Genotype-Phenotype Associations for Antibiotic Resistance in Mycobacterium abscessus. (PMID 36988496)