| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3007485 |
| Definition | Nigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux. |
| SMILES | CO[C@@H]1C[C@@H](C[C@H]2CC[C@H](C)[C@H]([C@@H](C)C(=O)O)O2)O[C@]2(O[C@](C)([C@H]3CC[C@@](C)([C@@H]4O[C@@H]([C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C)C[C@@H]4C)O3)C[C@H]2C)[C@@H]1C |
| PubChem | 34230 |
| ChEBI | 7569 |
| CAS | 28380-24-7 |
| ChEMBL | CHEMBL405862 |
| Drug Class | ionophore with antibiotic activity |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + ionophore with antibiotic activity [Drug Class] |
| Publications | Umeyama H, et al. 2023. Anticancer Res 43(6):2455-2465 Nigericin Induces Apoptosis in Primary Effusion Lymphoma Cells by Mitochondrial Membrane Hyperpolarization and β-Catenin Destabilization. (PMID 37247906) |
| Curator | Description | Most Recent Edit |
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