nigericin [Antibiotic]

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Accession ARO:3007485
DefinitionNigericin is an antibiotic derived from Streptomyces hygroscopicus. It is described as a potassium ionophore, which facilitates H+/K+ anti-port across cell membranes, thereby activating NLRP3 by causing potassium efflux.
Drug Classionophore with antibiotic activity
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show

Umeyama H, et al. 2023. Anticancer Res 43(6):2455-2465 Nigericin Induces Apoptosis in Primary Effusion Lymphoma Cells by Mitochondrial Membrane Hyperpolarization and β-Catenin Destabilization. (PMID 37247906)