polyene antibiotic [Drug Class]

Accession ARO:3007497
DefinitionPolyenes are a group of antibiotics, particularly antifungals, that bind ergosterol, a fungal-specific sterol in the plasma membrane of fungi, causing the efflux of potassium and cell death. They were discovered in the 1930s by Richard Kuhn. They are primarily used for therapy for invasive fungal infections like invasive aspergillosis, cryptococcosis blastomycosis, etc. The two main polyenes are amphotericin B and nystatin.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ amphotericin B [Antibiotic]
+ nystatin [Antibiotic]

Carolus H, et al. 2020. J Fungi (Basel) 6(4): Amphotericin B and Other Polyenes-Discovery, Clinical Use, Mode of Action and Drug Resistance. (PMID 33261213)