Accession | ARO:3007540 |
Definition | Cyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria. |
Classification | 1 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show |
Sub-Term(s) | 3 ontology terms | Show |
Publications | Samukawa N, et al. 2022. Microbiology (Reading) 168(12): An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs. (PMID 36748577) Barbie P, et al. 2016. Org Biomol Chem 14(25):6036-54 Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities. (PMID 27241518) |
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