cyclomarin antibiotics [Drug Class]

Accession ARO:3007540
DefinitionCyclomarins are cyclic heptapeptides containing four unusual amino acids. Cyclomarins target two different targets: Clp C1, a subunit of the caseinolytic protease of Mycobacterium tuberculosis (MTB), and PfAp3Ase of Plasmodium falciparum. Therefore, cyclomarins are interesting lead structures for the development of drugs against tuberculosis and malaria.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
3 ontology terms | Show
+ cyclomarin A [Antibiotic]
+ cyclomarin B [Antibiotic]
+ cyclomarin C [Antibiotic]

Samukawa N, et al. 2022. Microbiology (Reading) 168(12): An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs. (PMID 36748577)

Barbie P, et al. 2016. Org Biomol Chem 14(25):6036-54 Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities. (PMID 27241518)