| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3007541 |
| Definition | Cyclomarin A was found to be bacteriocidal against bacteria replicating in culture broth and in human-derived macrophages and a series of multidrug resistant clinical isolates. It was identified as a potent antitubercular compound in a natural product whole cell screen. Importantly it kills both growing and dormant, non-replicating mycobacteria. |
| SMILES | C=C[C@H](C)C[C@@H]1NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](OC)c2ccccc2)NC(=O)[C@H](C)NC(=O)[C@H](C[C@@H](C)CO)N(C)C(=O)C[C@@H]([C@H](O)c2cn(C(C)(C)[C@@H]3CO3)c3ccccc23)NC1=O |
| PubChem | 10772429 |
| ChEBI | 182606 |
| ChEMBL | CHEMBL1241238 |
| Drug Class | cyclomarin antibiotics |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + cyclomarin antibiotics [Drug Class] |
| Publications | Samukawa N, et al. 2022. Microbiology (Reading) 168(12): An efficient CRISPR interference-based prediction method for synergistic/additive effects of novel combinations of anti-tuberculosis drugs. (PMID 36748577) Barbie P, et al. 2016. Org Biomol Chem 14(25):6036-54 Total synthesis of cyclomarins A, C and D, marine cyclic peptides with interesting anti-tuberculosis and anti-malaria activities. (PMID 27241518) |
| Curator | Description | Most Recent Edit |
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