antibiotic resistant ergosterol biosynthesis pathway transcription factor [AMR Gene Family]

Accession ARO:3007549
DefinitionFungal sterol regulatory element binding proteins are transcription factors that modulate antibiotic-susceptible genes. Mutations in these proteins confer resistance to antifungal drug compounds through differential gene regulation.
Drug Classtriazole antibiotic
Resistance Mechanismantibiotic target overexpression
Classification5 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ gene modulating azole resistance
+ participates_in antibiotic target overexpression [Resistance Mechanism]
+ confers_resistance_to_drug_class triazole antibiotic [Drug Class]
1 ontology terms | Show

Dunkel N, et al. 2008. Eukaryot Cell 7(7):1180-90 A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate. (PMID 18487346)