Accession | ARO:3007615 |
Definition | Pyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation. |
Drug Class | ionophore with antibiotic activity |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + ionophore with antibiotic activity [Drug Class] |
Sub-Term(s) | 13 ontology terms | Show + pyrrolomycin A [Antibiotic] + pyrrolomycin B [Antibiotic] + pyrrolomycin C [Antibiotic] + pyrrolomycin D [Antibiotic] + pyrrolomycin E [Antibiotic] + pyrrolomycin F [Antibiotic] + pyrrolomycin F2a [Antibiotic] + pyrrolomycin F2b [Antibiotic] + pyrrolomycin G [Antibiotic] + pyrrolomycin H [Antibiotic] + pyrrolomycin F3 [Antibiotic] + pyrrolomycin I [Antibiotic] + pyrrolomycin J [Antibiotic] |
Publications | Firsov AM, et al. 2022. Biochemistry (Mosc) 87(8):812-822 Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler. (PMID 36171648) |
Curator | Description | Most Recent Edit |
---|