pyrrolomycin antibiotic

Accession ARO:3007615
DefinitionPyrrolomycins are protonophore antibiotics produced by Actinosporangium and Streptomyces. The mechanism of their antimicrobial activity consists in depolarization of bacterial membrane, leading to the suppression of bacterial bioenergetics through the uncoupling of oxidative phosphorylation.
Drug Classionophore with antibiotic activity
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
13 ontology terms | Show
+ pyrrolomycin A [Antibiotic]
+ pyrrolomycin B [Antibiotic]
+ pyrrolomycin C [Antibiotic]
+ pyrrolomycin D [Antibiotic]
+ pyrrolomycin E [Antibiotic]
+ pyrrolomycin F [Antibiotic]
+ pyrrolomycin F2a [Antibiotic]
+ pyrrolomycin F2b [Antibiotic]
+ pyrrolomycin G [Antibiotic]
+ pyrrolomycin H [Antibiotic]
+ pyrrolomycin F3 [Antibiotic]
+ pyrrolomycin I [Antibiotic]
+ pyrrolomycin J [Antibiotic]

Firsov AM, et al. 2022. Biochemistry (Mosc) 87(8):812-822 Antibiotic Pyrrolomycin as an Efficient Mitochondrial Uncoupler. (PMID 36171648)