ascorbic acid [Adjuvant]

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Accession ARO:3007653
DefinitionThe production of pyocyanin by Pseudomonas aeruginosa increases its virulence, fitness and biofilm formation. Ascorbic acid combined with furanone-30 elevated quorum-sensing inhibition in P. aeruginosa, which was directly associated with significantly reduced virulence, adhesion, aggregation and biofilm formation and enhanced antibiotic-mediated bacterial killing.
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Das T, et al. 2023. Front Microbiol 14:1166607 Ascorbic acid modulates the structure of the Pseudomonas aeruginosa virulence factor pyocyanin and ascorbic acid-furanone-30 combination facilitate biofilm disruption. (PMID 37520362)