metal transporters with antibiotic efflux [AMR Gene Family]

Accession ARO:3007657
DefinitionEfflux pumps also regulate the level of metal ions in the cytoplasm but are toxic when in excess. Metals often act as a facilitator in the proliferation and persistence of antibiotic resistance. Therefore, metal contamination in natural environments could have an important role in maintaining and promoting antibiotic resistance. The presence of metals co-selects for antibiotic resistance and leads to the development of cross-resistance. Micro-organisms adopt various mechanisms that may confer resistance against more than one antimicrobial, of which multidrug efflux systems are the most common.
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show

Adhikary A, et al. 2022. Microbiology (Reading) 168(10): A NiCoT family metal transporter of Mycobacterium tuberculosis (Rv2856/NicT) behaves as a drug efflux pump that facilitates cross-resistance to antibiotics. (PMID 36282241)