nordihydroguaiaretic acid [Adjuvant]

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Accession ARO:3007745
DefinitionNordihydroguaiaretic acid (NDGA) is a phenolic lignan obtained from Larrea tridentata that has been used in traditional medicine for the treatment of diseases such as cancer, renal, cardiovascular, immunological, and neurological disorders, and even aging. The inhibition of NDM-1 by nordihydroguaiaretic acid involves its direct binding to the active region of NDM-1.
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Guo Y, et al. 2023. Br J Pharmacol : Novel metallo-β-lactamases inhibitors restore the susceptibility of carbapenems to New Delhi metallo-lactamase-1 (NDM-1)-harbouring bacteria. (PMID 37539785)