| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009544 |
| Definition | The Cyp51A enzyme plays a key role in sterol biosynthesis in fungi. While azoles target lanosterol demethylase to disrupt ergosterol production, carbendazim functions differently as a benzimidazole, binding to beta-tubulin and preventing microtubule assembly. Although Cyp51A is not directly involved in the benomyl target pathway, concurrent mutations in sterol biosynthesis genes like Cyp51A have been associated in some studies. |
| AMR Gene Family | benzimidazole resistant fungal cytochrome P450 enzyme |
| Drug Class | benzimidazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic target + antibiotic molecule + antibiotic resistance gene variant or mutant + benzimidazole antifungal [Drug Class] + fungal ergosterol synthesis pathway enzyme + antifungal-resistant cytochrome P450 enzyme |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic carbendazim [Antibiotic] + derives_from antifungal susceptible Cyp51 enzyme + benzimidazole resistant fungal cytochrome P450 enzyme [AMR Gene Family] |
| Curator | Description | Most Recent Edit |
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