tunicamycin [Antibiotic]

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Accession ARO:0000009
DefinitionTunicamycin is mixture of homologous nucleoside antibiotics that block the reaction of UDP-N-acetylglucosamine and dolichyl phosphate in the first step of glycoprotein synthesis.
Drug Classnucleoside antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show
+ tmrB confers_resistance_to_antibiotic
+ tunicamycin resistance protein [AMR Gene Family] confers_resistance_to_antibiotic

Noda Y, et al. 1992. J Bacteriol 174(13): 4302-4307. TmrB protein, responsible for tunicamycin resistance of Bacillus subtilis, is a novel ATP-binding membrane protein. (PMID 1624425)