| Accession | ARO:3003059 |
| CARD Short Name | tmrB |
| Definition | tmrB is an ATP-binding tunicamycin resistance protein found in Bacillus subtilis. |
| AMR Gene Family | tunicamycin resistance protein |
| Drug Class | nucleoside antibiotic |
| Resistance Mechanism | reduced permeability to antibiotic |
| Resistomes with Perfect Matches | Bacillus subtilisg+wgs |
| Resistomes with Sequence Variants | Bacillus subtilisg+wgs, Bacillus tequilensiswgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + determinant of antibiotic resistance + nucleoside antibiotic [Drug Class] + antibiotic mixture + tunicamycin [Antibiotic] + protein modulating permeability to antibiotic |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic tunicamycin [Antibiotic] + tunicamycin resistance protein [AMR Gene Family] |
| Publications | Noda Y, et al. 1995. Biosci Biotechnol Biochem 59(2): 321-322. TmrB protein, which confers resistance to tunicamycin on Bacillus subtilis, binds tunicamycin. (PMID 7766032) |
Prevalence of tmrB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus subtilis | 91.4% | 0% | 65.03% | 0% |
| Bacillus tequilensis | 0% | 0% | 66.67% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 375