ceftobiprole [Antibiotic]

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Accession ARO:0000061
Synonym(s)Ceftobiprole medocaril Zevtera Zeftera
DefinitionCeftobiprole (Zeftera/Zevtera) is a next generation (5th generation) cephalosporin antibiotic with activity against methicillin-resistant Staphylococcus aureus, penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and Enterococci. Ceftobiprole inhibits transpeptidases essential to building cell walls, and is a poor substrate for most beta-lactamases.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
Sub-Term(s)
1 ontology terms | Show
Publications

Stucki A, et al. 2012. Antimicrob Agents Chemother 56(2): 921-925. Evaluation of ceftobiprole activity against a variety of gram-negative pathogens, including Escherichia coli, Haemophilus influenzae (beta-lactamase positive and beta-lactamase negative), and Klebsiella pneumoniae, in a rabbit meningitis model. (PMID 22064544)