emrE

Accession ARO:3000264
DefinitionEmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. EmrE is found in E. coli and P. aeruginosa.
AMR Gene Familysmall multidrug resistance (SMR) antibiotic efflux pump
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification5 ontology terms | Show
Parent Term(s)1 ontology terms | Show
Sub-Term(s)
2 ontology terms | Show
Publications

Ma C and Chang G. 2007. Proc Natl Acad Sci U S A 104(9): 3668. Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli. (PMID 17360700)

Bay DC, et al. 2008. Biochim Biophys Acta 1778(9): 1814-1838. Small multidrug resistance proteins: a multidrug transporter family that continues to grow. (PMID 17942072)

Nara T, et al. 2007. J Biochem 142(5): 621-625. Anti-parallel membrane topology of a homo-dimeric multidrug transporter, EmrE. (PMID 18006522)

Schuldiner S. 2009. Biochim Biophys Acta 1794(5): 748-762. EmrE, a model for studying evolution and mechanism of ion-coupled transporters. (PMID 19167526)

Korkhov VM and Tate CG. 2009. Acta Crystallogr D Biol Crystallogr 65(PT 2): 186-192. An emerging consensus for the structure of EmrE. (PMID 19171974)

Agarwal V, et al. 2007. Biochim Biophys Acta 1768(12): 3036-3043. MAS solid-state NMR studies on the multidrug transporter EmrE. (PMID 17976529)

Li XZ, et al. 2003. Antimicrob. Agents Chemother. 47(1):27-33 Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes. (PMID 12499164)