Pseudomonas aeruginosa emrE

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Accession ARO:3004038
Synonym(s)Pae-Emre PAsmr
CARD Short NamePaer_emrE
DefinitionEmrE is a small multidrug transporter that functions as a homodimer and that couples the efflux of small polyaromatic cations from the cell with the import of protons down an electrochemical gradient. Confers resistance to tetraphenylphosphonium, methyl viologen, gentamicin, kanamycin, and neomycin.
AMR Gene Familysmall multidrug resistance (SMR) antibiotic efflux pump
Drug Classaminoglycoside antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesPseudomonas aeruginosag+wgs, Pseudomonas fluorescensg
Resistomes with Sequence VariantsAcinetobacter baumanniiwgs, Acinetobacter pittiiwgs, Neisseria meningitidiswgs, Pseudomonas aeruginosag+wgs, Pseudomonas fluorescensg, Stenotrophomonas maltophiliawgs
Classification10 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ emrE
+ confers_resistance_to_antibiotic gentamicin C [Antibiotic]

Li XZ, et al. 2003. Antimicrob. Agents Chemother. 47(1):27-33 Contributions of MexAB-OprM and an EmrE homolog to intrinsic resistance of Pseudomonas aeruginosa to aminoglycosides and dyes. (PMID 12499164)


Prevalence of Pseudomonas aeruginosa emrE among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 377 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Acinetobacter baumannii0%0%0.02%0%
Acinetobacter pittii0%0%0.33%0%
Neisseria meningitidis0%0%0.05%0%
Pseudomonas aeruginosa100%0%75.36%0%
Pseudomonas fluorescens2.86%0%0%0%
Stenotrophomonas maltophilia0%0%0.52%0%
Show Perfect Only

Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 170

>gb|AAG08375.1|+|Pseudomonas aeruginosa emrE [Pseudomonas aeruginosa PAO1]

>gb|AE004091.2|+|5606103-5606435|Pseudomonas aeruginosa emrE [Pseudomonas aeruginosa PAO1]