antibiotic-resistant isoleucyl-tRNA synthetase (ileS) [AMR Gene Family]

Accession ARO:3000446
DefinitionMupirocin inhibits protein synthesis by interfering with isoleucyl-tRNA synthetase (ileS). Mutations in ileS can confer low-level mupirocin resistance.
Drug Classmupirocin-like antibiotic
Resistance Mechanismantibiotic target alteration
Classification6 ontology terms | Show
Parent Term(s)3 ontology terms | Show
4 ontology terms | Show

Udo EE, et al. 2001. J Med Microbiol 50(10): 909-915. Genetic analysis of methicillin-resistant Staphylococcus aureus expressing high- and low-level mupirocin resistance. (PMID 11599741)

Hodgson JE, et al. 1994. Antimicrob Agents Chemother 38(5): 1205-1208. Molecular characterization of the gene encoding high-level mupirocin resistance in Staphylococcus aureus J2870. (PMID 8067768)

Seah C, et al. 2012. Antimicrob Agents Chemother 56(4): 1916-1920. MupB, a New High-Level Mupirocin Resistance Mechanism in Staphylococcus aureus. (PMID 22252810)

Serafini F, et al. 2011. Appl Environ Microbiol 77(9): 3141-3146. Insights into physiological and genetic mupirocin susceptibility in bifidobacteria. (PMID 21421794)

Antonio M, et al. 2002. Antimicrob. Agents Chemother. 46(2):438-42 Mutations affecting the Rossman fold of isoleucyl-tRNA synthetase are correlated with low-level mupirocin resistance in Staphylococcus aureus. (PMID 11796355)