antibiotic sensitive Isoleucyl-tRNA transferase

Accession ARO:3000732
DefinitionIsoleucyl-tRNA transferase recognizes isoleucine codons and works with the ribosome to incorporate isoleucine amino acids into polypeptide chains. It can be targeted by antibiotics that have an analog of isoleucine through competitive inhibition.
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ targeted_by_antibiotic mupirocin [Antibiotic]
+ protein synthesis machinery targeted by antibiotic
1 ontology terms | Show

Yanagisawa T, et al. 1994. J Biol Chem 269(39): 24304-24309. Relationship of protein structure of isoleucyl-tRNA synthetase with pseudomonic acid resistance of Escherichia coli. A proposed mode of action of pseudomonic acid as an inhibitor of isoleucyl-tRNA synthetase. (PMID 7929087)

Yarus M and Berg P. 1969. J Mol Biol 42(2): 171-189. Recognition of tRNA by isoleucyl-tRNA synthetase. Effect of substrates on the dynamics of tRNA-enzyme interaction. (PMID 5803296)