FomB

Accession ARO:3000449
DefinitionAn enzyme which on its own cannot provide fosfomycin resistance, however in conjunction with FomA, it leads to the formation of fosfomycin with three phosphates total, which makes it inactive.
AMR Gene FamilyFom phosphotransferase family
Drug Classfosfomycin
Resistance Mechanismantibiotic inactivation
Classification12 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic fosfomycin [Drug Class]
+ Fom phosphotransferase family [AMR Gene Family]
Publications

Pakhomova S, et al. 2008. J Biol Chem 283(42): 28518-28526. Crystal structure of fosfomycin resistance kinase FomA from Streptomyces wedmorensis. (PMID 18701452)

Resistomes

Prevalence of FomB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 500


>gb|BAA32494.1|+|FomB [Streptomyces wedmorensis]
MLENLTIRSSRVVDLNLVKVRLSTNLEDFAAYSYFSAFAEDESAPADYEVVCVDLDRDDIPAELYADRTDRTFRGKRFKGGYYLVHYFGE
PAHLITVGRTFYVFGRSLEKTVWPYFVKHILTVHSADHGFLHLKAAGFELPGAGATLLVGRNGAGKTVFLAQACLNGARFLSNTHTLVRD
GVAHGVPSSIRVRRDQCFGELIDKHDLTAHMESGDYVTDSSTLFESPQISTARVRNVVIVDYDPARPQGLMPISPAAAGTFMEQFSFAVT
TYGLKDDLLAHHGDFDTYVDSLARMRAQLTELVEGARCYRANADMLAKEVRDSTLKQLAE


>gb|AB016934|+|7389-8381|FomB [Streptomyces wedmorensis]
ATGCTGGAAAACCTCACGATCCGCAGCAGCCGCGTCGTCGACCTCAACCTGGTCAAGGTCAGGCTGTCCACCAACCTCGAGGACTTCGCG
GCGTACTCCTACTTCTCGGCCTTCGCCGAGGACGAGTCCGCGCCCGCCGACTACGAGGTCGTCTGCGTCGACCTGGACCGGGACGACATC
CCGGCCGAGCTGTACGCCGACCGGACCGACCGGACCTTCCGCGGCAAGCGGTTCAAGGGCGGCTACTACCTCGTCCACTACTTCGGGGAG
CCCGCCCACCTCATCACGGTGGGCCGCACGTTCTACGTGTTCGGCAGGTCCCTCGAGAAGACCGTCTGGCCCTACTTCGTCAAGCACATC
CTGACCGTCCACTCCGCGGACCACGGCTTCCTGCACCTGAAGGCGGCGGGCTTCGAACTGCCCGGCGCCGGAGCCACCCTGCTCGTCGGG
CGCAACGGCGCGGGGAAGACCGTCTTCCTGGCCCAGGCGTGCCTCAACGGCGCCCGGTTCCTCAGCAACACCCACACGCTGGTCCGGGAC
GGGGTCGCGCACGGCGTCCCCTCCTCGATCCGGGTGCGCCGCGACCAGTGCTTCGGTGAACTCATCGACAAGCACGACCTGACGGCGCAC
ATGGAGTCGGGCGACTACGTCACCGACTCCTCGACTCTCTTCGAGAGTCCGCAGATCAGCACGGCACGCGTCCGGAACGTCGTCATCGTC
GACTACGACCCCGCACGCCCCCAGGGCCTCATGCCGATCTCGCCGGCCGCGGCCGGCACCTTCATGGAGCAGTTCTCCTTCGCGGTCACC
ACCTACGGCCTCAAGGACGATCTGCTCGCCCACCACGGGGACTTCGACACCTACGTCGACTCCCTGGCCCGGATGCGGGCGCAGCTGACC
GAACTGGTCGAGGGCGCGCGCTGCTACCGGGCCAACGCAGACATGCTGGCCAAGGAAGTCCGGGATTCGACGCTCAAGCAGCTTGCCGAA
TGA