tuberactinomycin [Antibiotic]

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Accession ARO:3000490
DefinitionTuberactinomycins are a family of cyclic peptide antibiotics that are important in the treatment of tuberculosis. Tuberactinomycins contain nonproteinogenic amino acids and inhibit group I self-splicing RNA to disrupt prokaryotic protein synthesis.
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
2 ontology terms | Show
+ RNA guanosine binding site targeted_by_antibiotic
+ ribosomal complex targeted_by_antibiotic

Thomas MG, et al. 2003. Antimicrob Agents Chemother 47(9): 2823-2830. Deciphering tuberactinomycin biosynthesis: isolation, sequencing, and annotation of the viomycin biosynthetic gene cluster. (PMID 12936980)

Wank H, et al. 1994. J Mol Biol 236(4): 1001-1010. Peptide antibiotics of the tuberactinomycin family as inhibitors of group I intron RNA splicing. (PMID 7509881)