fosfomycin sensitive pyruvyl transferase (murA)

Accession ARO:3000724
DefinitionPyruvyl transferase is responsible for the conversion of N-acetylglucosamine (NAG) to N-acetylmuramic acid (NAMA). NAMA is a part of the macromolecular backbone of peptidoglycans. Pyruvyl transferase is found in both Gram-positive and Gram-negative bacteria.
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ cell wall synthesis enzyme targeted by antibiotic
+ targeted_by_antibiotic fosfomycin [Antibiotic]
1 ontology terms | Show
+ antibiotic-resistant murA transferase [AMR Gene Family] derives_from

Kahan FM, et al. 1974. Ann N Y Acad Sci 235: 364-386. The mechanism of action of fosfomycin (phosphonomycin). (PMID 4605290)