antibiotic-resistant murA transferase [AMR Gene Family]

Accession ARO:3002811
DefinitionmurA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance.
Drug Classfosfomycin
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ confers_resistance_to_drug_class fosfomycin [Drug Class]
+ antibiotic resistant gene variant or mutant
+ derives_from fosfomycin sensitive pyruvyl transferase (murA)
5 ontology terms | Show

Takahata S, et al. 2010. Int J Antimicrob Agents 35(4): 333-337. Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli. (PMID 20071153)