murA transferase [AMR Gene Family]

Accession ARO:3002811
DefinitionmurA or UDP-N-acetylglucosamine enolpyruvyl transferase catalyses the initial step in peptidoglycan biosynthesis and is inhibited by fosfomycin. Overexpression of murA through mutations confers fosfomycin resistance.
Drug Classfosfomycin
Resistance Mechanismantibiotic target alteration
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
Sub-Term(s)
5 ontology terms | Show
Publications

Takahata S, et al. 2010. Int J Antimicrob Agents 35(4): 333-337. Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli. (PMID 20071153)