| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3001236 |
| Definition | Efrotomycin is produced by Streptomyces lactamodurans NRRL 3802. This kirromycin-like antibiotic is used in animal agriculture, especially in the production of swine. Generally gram negative bacteria are susceptible to efrotomycin, while gram positive bacteria are resistant. |
| SMILES | C/C=C/C=C/[C@@H]1O[C@](O)([C@H](CC)C(=O)NC/C=C/C=C(\C)[C@@H](OC)[C@@H](C)[C@@H]2O[C@H](/C=C/C=C/C=C(\C)C(=O)c3c(O)ccn(C)c3=O)[C@H](O)[C@@H]2O)[C@H](O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC)[C@@H](O)[C@H]3OC)[C@@H](OC)[C@H]2O)C1(C)C |
| PubChem | 135434844 |
| ChEMBL | CHEMBL2106443 |
| Drug Class | elfamycin antibiotic |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Publications | Sarmah AK, et al. 2006. Chemosphere 65(5): 725-759. A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. (PMID 16677683) Wax R, et al. 1976. J Antibiot (Tokyo) 29(6): 670-673. Efrotomycin, a new antibiotic from Streptomyces lactamdurans. (PMID 950325) Landini P, et al. 1993. J Gen Microbiol 139(4): 769-774. Sensitivity of elongation factor Tu (EF-Tu) from different bacterial species to the antibiotics efrotomycin, pulvomycin and MDL 62879. (PMID 8515234) Landini P, et al. 1992. Biochem J 283(PT 3): 649-652. Inhibition of bacterial protein synthesis by elongation-factor-Tu-binding antibiotics MDL 62,879 and efrotomycin. (PMID 1590753) |
| Curator | Description | Most Recent Edit |
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