kirromycin-like antibiotics

Accession ARO:3001310
DefinitionKirromycin-like antibiotics bind to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted.
Drug Classelfamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ elfamycin antibiotic [Drug Class]
22 ontology terms | Show
+ L-681,217 [Antibiotic]
+ aurodox [Antibiotic]
+ azimycin [Antibiotic]
+ dihydromocimycin [Antibiotic]
+ efrotomycin [Antibiotic]
+ factumycin [Antibiotic]
+ heneicomycin [Antibiotic]
+ kirrothricin [Antibiotic]
+ phenelfamycin A [Antibiotic]
+ phenelfamycin B [Antibiotic]
+ phenelfamycin C [Antibiotic]
+ phenelfamycin D [Antibiotic]
+ phenelfamycin E [Antibiotic]
+ phenelfamycin F [Antibiotic]
+ unphenelfamycin [Antibiotic]
+ kirromycin [Antibiotic]
+ SB22484 [Antibiotic]
+ UK-69,753 [Antibiotic]
+ phenelfamycin G [Antibiotic]
+ phenelfamycin H [Antibiotic]
+ ganefromycin [Antibiotic]
+ elongation factor Tu targeted_by_antibiotic