elfamycin antibiotic [Drug Class]

Accession ARO:3001219
DefinitionElfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
7 ontology terms | Show
+ pulvomycin [Antibiotic]
+ enacyloxin IIa [Antibiotic]
+ cyclic thiazolyl peptide elfamycin
+ kirromycin-like antibiotics
+ elongation factor Tu targeted_by
+ elfamycin resistant EF-Tu [AMR Gene Family] confers_resistance_to_drug_class
+ kirromycin self resistant EF-Tu [AMR Gene Family] confers_resistance_to_drug_class

Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016)

Parmeggiani A and Nissen P. 2006. FEBS Lett 580(19): 4576-4581. Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action. (PMID 16876786)