| Accession | ARO:3001219 |
| Synonym(s) | elfamycin |
| Definition | Elfamycins are molecules that inhibit bacterial elongation factor Tu (EF-Tu), a key protein which brings aminoacyl-tRNA (aa-tRNA) to the ribosome during protein synthesis. Elfamycins defined by their target (EF-Tu), rather than a conserved chemical backbone. Elfamycins follow two mechanisms to disrupt protein synthesis: 1. kirromycins and enacyloxin fix EF-Tu in the GTP bound conformation and lock EF-Tu onto the ribosome, and 2. pulvomycin and GE2270 cover the binding site of aa-tRNA disallowing EF-Tu from being charged with aa-tRNA. All elfamycins cause increased the affinity of EF-Tu for GTP. |
| Classification | 1 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 7 ontology terms | Show + pulvomycin [Antibiotic] + enacyloxin IIa [Antibiotic] + cyclic thiazolyl peptide elfamycin + kirromycin-like antibiotics + elongation factor Tu targeted_by + elfamycin resistant EF-Tu [AMR Gene Family] confers_resistance_to_drug_class + kirromycin self resistant EF-Tu [AMR Gene Family] confers_resistance_to_drug_class |
| Publications | Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016) Parmeggiani A and Nissen P. 2006. FEBS Lett 580(19): 4576-4581. Elongation factor Tu-targeted antibiotics: four different structures, two mechanisms of action. (PMID 16876786) |