enacyloxin IIa [Antibiotic]

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Accession ARO:3001242
DefinitionEnacyloxin IIa is structurally distinct but acts in a similar mechanism to kirromycin-like elfamycins. It prohibits the transfer of the amino acid at the A site to the elongating peptide chain. It is most likely that the mechanism of action is that EF-Tu*GDP is locked in the EF-Tu*GTP form, and EF-Tu*GDP*aa-tRNA is immobilized on the ribosome. It is an open question whether enacyloxin IIa actually belongs to the kirromycin-like group of elfamycins due to their high similarity.
Drug Classelfamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ elfamycin antibiotic [Drug Class]
2 ontology terms | Show
+ Escherichia coli EF-Tu mutants conferring resistance to Enacyloxin IIa confers_resistance_to_antibiotic
+ elongation factor Tu targeted_by_antibiotic

Cetin R, et al. 1996. EMBO J 15(10): 2604-2611. Enacyloxin IIa, an inhibitor of protein biosynthesis that acts on elongation factor Tu and the ribosome. (PMID 8665868)

Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016)