pulvomycin [Antibiotic]

Download Sequences

Accession ARO:3000586
DefinitionPulvomycin is a polyketide antibiotic that binds elongation factor Tu (EF-Tu) to inhibit protein biosynthesis by preventing the formation of the ternary complex (EF-Tu*GTP*aa-tRNA). Phenotypically, it was shown that pulvomycin sensitivity is dominant over resistance.
Drug Classelfamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ elfamycin antibiotic [Drug Class]
2 ontology terms | Show
+ Escherichia coli EF-Tu mutants conferring resistance to Pulvomycin confers_resistance_to_antibiotic
+ elongation factor Tu targeted_by_antibiotic

Parmeggiani A, et al. 2006. Biochemistry 45(22): 6846-6857. Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu. (PMID 16734421)

Wolf H, et al. 1978. Proc Natl Acad Sci U S A 75(11): 5324-5328. Pulvomycin, an inhibitor of protein biosynthesis preventing ternary complex formation between elongation factor Tu, GTP, and aminoacyl-tRNA. (PMID 364475)

Anborgh PH, et al. 2004. Biochemistry 43(49): 15550-15556. Effects of the antibiotic pulvomycin on the elongation factor Tu-dependent reactions. Comparison with other antibiotics. (PMID 15581367)

Zeef LA, et al. 1994. EMBO J 13(21): 5113-5120. Pulvomycin-resistant mutants of E.coli elongation factor Tu. (PMID 7957075)