elfamycin resistant EF-Tu [AMR Gene Family]

Accession ARO:3001312
DefinitionSequence variants of elongation factor Tu that confer resistance to elfamycin antibiotics.
Drug Classelfamycin antibiotic
Resistance Mechanismantibiotic target alteration
Classification7 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ derives_from elongation factor Tu
+ confers_resistance_to_drug_class elfamycin antibiotic [Drug Class]
+ Antibiotic resistant EF-Tu
5 ontology terms | Show

Zuurmond AM, et al. 1999. J Mol Biol 294(3): 627-637. Mutant EF-Tu species reveal novel features of the enacyloxin IIa inhibition mechanism on the ribosome. (PMID 10610785)

Abdulkarim F, et al. 1994. FEBS Lett 352(2): 118-122. Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP. (PMID 7925958)

Zeef LA, et al. 1994. EMBO J 13(21): 5113-5120. Pulvomycin-resistant mutants of E.coli elongation factor Tu. (PMID 7957075)

Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016)

Mesters JR, et al. 1994. EMBO J 13(20): 4877-4885. The structural and functional basis for the kirromycin resistance of mutant EF-Tu species in Escherichia coli. (PMID 7525272)

Sosio M, et al. 1996. Mol Microbiol 22(1): 43-51. An elongation factor Tu (EF-Tu) resistant to the EF-Tu inhibitor GE2270 in the producing organism Planobispora rosea. (PMID 8899707)