cyclic thiazolyl peptide elfamycin

Accession ARO:3001309
DefinitionCyclic thiazolyl peptide elfamycins inhibit protein synthesis by preventing the formation of the EF-Tu*GTP-aa-tRNA ternary complex, a mechanism similar to that of pulvomycin. There are non-elfamycin cyclic thiazolyl peptide antibiotics which inhibit protein synthesis by by targeting the 50S ribosomal subunit and are not discussed here further.
Drug Classelfamycin antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ elfamycin antibiotic [Drug Class]
4 ontology terms | Show
+ GE37468 [Antibiotic]
+ amythiamicin A [Antibiotic]
+ GE2270A [Antibiotic]
+ LFF571 [Antibiotic]

Hogg T, et al. 2002. Curr Protein Pept Sci 3(1): 121-131. Inhibitory mechanisms of antibiotics targeting elongation factor Tu. (PMID 12370016)